John's Wort (Hypericum perforatum) may possibly improve the metabolism of tricyclic antidepressants and result in reduced plasma amounts of tricyclic antidepressants and reduced antidepressant reaction. In the presence of ethanol amitriptyline free plasma concentrations and nortriptyline concentrations ended up amplified. Amitriptyline plasma focus could be greater by sodium valproate... https://jonahh221vlc0.wikicorrespondence.com/user