Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other indicators in the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have identified recurrent mutations in genes regulating tumor mobile-microenvironment interactions... https://abbaa938fpw4.wikiap.com/user